| Date/Time/Field | Score | Home Team | | Visiting Team | Score |
|---|
| Tuesday, Sep 07, 2021 |
| 06:00 PM-07:15 PM - Springfield Park Springfield Park Football Field | 26 | Mauldin Mavericks | vs | Mauldin Tigers | 14 |
| Wednesday, Sep 08, 2021 |
| 06:00 PM-07:15 PM - Emmanuel Sullivan ESC Football Field | 25 | Fountain Inn Fury | vs | Greer Junior Jackets | 18 |
| Thursday, Sep 09, 2021 |
| 06:00 PM-07:15 PM - Springfield Park Springfield Park Football Field | 35 | Mauldin Mavericks | vs | Simpsonville Bruins | 20 |
| Monday, Sep 13, 2021 |
| 06:00 PM-07:15 PM - Greer City Stadium Football Field | 19 | Greer Junior Jackets | vs | Mauldin Tigers | 13 |
| Thursday, Sep 16, 2021 |
| 06:00 PM-07:15 PM - Emmanuel Sullivan ESC Football Field | 34 | Fountain Inn Fury | vs | Mauldin Mavericks | 20 |
| Monday, Sep 20, 2021 |
| 06:00 PM-07:15 PM - Simpsonville City Park Simpsonville City Park Football Field | 0 | Simpsonville Bruins | vs | Mauldin Tigers | 12 |
| 06:00 PM-07:15 PM - Springfield Park Springfield Park Football Field | 27 | Mauldin Mavericks | vs | Greer Junior Jackets | 14 |
| Thursday, Sep 23, 2021 |
| 06:00 PM-07:15 PM - Simpsonville City Park Simpsonville City Park Football Field | 14 | Simpsonville Bruins | vs | Fountain Inn Fury | 32 |
| Monday, Sep 27, 2021 |
| 06:00 PM-07:15 PM - Simpsonville City Park Simpsonville City Park Football Field | 20 | Simpsonville Bruins | vs | Greer Junior Jackets | 0 |
| 06:00 PM-07:15 PM - Springfield Park Springfield Park Football Field | 13 | Mauldin Tigers | vs | Mauldin Mavericks | 26 |
| Thursday, Sep 30, 2021 |
| 06:00 PM-07:15 PM - Springfield Park Springfield Park Football Field | 20 | Mauldin Tigers | vs | Fountain Inn Fury | 28 |
| Monday, Oct 04, 2021 |
| 06:00 PM-07:15 PM - Emmanuel Sullivan ESC Football Field | 34 | Fountain Inn Fury | vs | Simpsonville Bruins | 7 |
| 06:00 PM-07:15 PM - Greer City Stadium Football Field | 7 | Greer Junior Jackets | vs | Mauldin Mavericks | 20 |
| Thursday, Oct 07, 2021 |
| 06:00 PM-07:15 PM - Emmanuel Sullivan ESC Football Field | 33 | Fountain Inn Fury | vs | Mauldin Tigers | 7 |
| Monday, Oct 11, 2021 |
| 06:00 PM-07:15 PM - Springfield Park Springfield Park Football Field | 6 | Mauldin Tigers | vs | Greer Junior Jackets | 14 |
| Tuesday, Oct 12, 2021 |
| 06:00 PM-07:15 PM - Greer City Stadium Football Field | 30 | Greer Junior Jackets | vs | Simpsonville Bruins | 26 |
| 06:00 PM-07:15 PM - Springfield Park Springfield Park Football Field | 20 | Mauldin Mavericks | vs | Fountain Inn Fury | 36 |
| Thursday, Oct 14, 2021 |
| 06:00 PM-07:15 PM - Springfield Park Springfield Park Football Field | 24 | Mauldin Tigers | vs | Simpsonville Bruins | 25 |
| Monday, Oct 18, 2021 |
| 06:00 PM-07:15 PM - Greer City Stadium Football Field | 0 | Greer Junior Jackets | vs | Fountain Inn Fury | 20 |
| Tuesday, Oct 19, 2021 |
| 06:00 PM-07:15 PM - Simpsonville City Park Simpsonville City Park Football Field | 7 | Simpsonville Bruins | vs | Mauldin Mavericks | 20 |
